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The Standard Group of Companies design and manufacture Barrier Isolators and Glove Boxes for the Pharmaceutical and Chemical Industries.

The Schematic part of the business uses client specific requirements and follow cGMP and cGAMP standards for standard and bespoke applications.

Both of these pieces of equipment are used widely in similar applications however are fundamentally different.

Glove boxes

A glove box is a sealed container that allows for the handling of objects where a separate environment is required.

They are commonly used to protect workers from hazardous materials or to protect chemicals and materials that may be sensitive to air or water vapor.

Glove boxes may be used under either positive or negative pressure.

Glove boxes operated under positive pressure usually contain materials which are very susceptible to outside contaminates.

Exposure to outside contaminates can lead to a negative effect on the compound being used.

Negative pressure glove boxes are used to protect workers and are used for hazardous and toxic materials like pathogens.

Gloves are built into the glove box and placed so that that the user can manipulate and perform tasks inside the box without breaking containment.

Glove boxes have transparent parts and allow the user to see what is being handled.

These transparent parts are usually fragile and can break in operation.

Schematic industries glove boxes 1

 

Barrier Isolators

Again, the operation requires the handling of gloves so users can work in accordance with procedures for that process, however this manipulation and view of work in progress is in a sealed and separate environment.

Unlike simple glove boxes, barrier isolators are usually built with stainless steel, are welded and in certain cases the transparent clear parts are substituted with tempered glass or other materials that provide a greater degree of operator safety.

A barrier isolator provides a physical barrier between personnel and the compounding activity where there is the possibility that altercations in the room airflow or poor aseptic technique by the user will introduce contaminants to the work area.

An isolator provides an additional level of protection as the sterile product is not exposed to the room environment or to compounding operator directly. When using an isolator material is passed into the main working chamber through an enclosed pass-thru chamber and accessed through glove ports to perform aseptic manipulations.

Standard Group sterility test barrier isolator 1

 

 Key differences between a Glove Box and a Barrier Isolator

Version 3 glove box

For more information click here or contact our offices in India or the UK.