The Standard Group of Companies are specialists at manufacturing bespoke, client specific Barrier Isolator systems to cGMP and cGAMP standards.
Negative Pressure Isolator Systems are a key part of the Schematic Engineering Industries capabilities.
Negative pressure barrier isolators are essential where the process media is hazardous, dangerous or has an unacceptably high toxic level.
This negative pressure inside the isolator is lower than its surroundings, air is allowed to flow into the isolator but toxic air is not allowed to escape.
Additionally -VE pressure reduces the chances of airborne toxins from escaping the isolator and entering the cleanroom environment which will be harmful to any operators.
Basically air will always flow from area's with higher pressure to area's with lower pressure and this principle stops contaminated air from escaping the closed environment.
In a negative air pressure containment system, the -ve pressure is achieved by inputting an inlet of air at 10-30 per cent lower than the supply air.
These isolator types are used in both API and formulation sectors of the pharmaceutical industry.
API isolators include: -
Dispensing & Sampling Isolators
Reactor Charging Isolator
ANFD Discharge Isolator
Centrifuge & Distillation Isolators
Filtration & Drying Isolators
Formulation isolators include: -
Granulation Isolator
QC Isolator
Milling & Blending Isolator
Pack off Isolator
Sieving & Weighing Isolators
Key parts of the technical specification include: -
SO 14644-1: class ISO 5 (Class 100, Grade A)
Low pressure and high-pressure alarm
Filter choked alarm
Interlocked door system
HEPA Filters
OEL Categories OEL 1-5
Light Vacuum (100 Pa) system
Typical applications:-
Pilot plant and laboratory equipment
Toxic Agrochemical applications
Filter Dryers and Fluid Bed Dryers (FBD's)
Micronizes, Multi-milling, Pulverising, Jet milling, Sieving and Weighing
Handling Cytotoxic drugs
Oncology drugs and Pack-off
Aseptic and Asepsis processes
Electronics Manufacturing
Beverage / Juice processing
Food Research & Development labs
Dispensing and Sampling
Benefits of negative -VE Barrier Isolators:-
Stable and accurate results
Clear visibility during operation and cleaning
Operator safety - fully interlocked air-locks, doors and visors
Uncontaminated process media
cGAMP - Alarms and safety measures in case of breach
Negative pressure isolators have become less common over time but are still more effective than more traditional methods which are vulnerable to contamination and can expose the worker to harmful hazards if not operated properly.
